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  1. Integrated analysis of breast cancer cell lines reveals unique signaling pathways

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    16 Sep 2014 | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman

    AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...

  2. Integrative Cancer Biology Program Datasets

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    26 Apr 2016 | Series | Contributor(s): Jonathan Bistline, Michael Reich

    The NCI-ICBP promotes an integrative/systems approach to the study of cancer biology. The Program encourages scientists to study cancer as a complex biological system. Information gained from these studies are used to build reliable and testable predictive computation models of cancer processes...

  3. Introduction to the Trinity Cancer Transcriptome Analysis Toolkit

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    05 Feb 2015 | Teaching Materials | Contributor(s): Brian Haas, Aviv Regev, Bill Barnett

    This short video provides an overview of our ITCR-funded effort to leverage RNA-Seq and de novo transcriptome assembly to assist researchers in studying cancer transcriptomes.  Visit our NCGAS Trinity/Galaxy portal to access these compute...

  4. ITCR Monthly Teleconference September 4, 2015

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    07 Oct 2015 | Presentations | Contributor(s): Juli Klemm

     

  5. ITCR PI Meeting June 2014 Presentations

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    23 Jun 2014 | Series

    Informatics Technology for Cancer Research (ITCR) Initiative held its Annual PI Meeting on June 12-13, 2014 in Rockville, MD. This series contains the presentations given at the meeting.

  6. LBL ICBP50 integrative genomic data

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    13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline

    From Joe Gray, Lawrence Berkeley National Laboratory.  There are seventeen (17) files in this study: Affymetrix U133A gene expression data (icbp_u133a.gct) Affymetrix U133A gene expression data (ICBP_U133a.zip) Affymetrix splice junction exon-exon data (ICBP_Junction.zip) Affymetrix...

  7. Life after MOOCS: Online Science Education Needs a New Revolution

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    03 Feb 2017 | Presentations | Contributor(s): Phillip Compeau

    ITCR Monthly PI Meeting, February 3, 2017 Presentation by Phillip Compeau (Carnegie Mellon U.)

  8. NCIP Hub Dashboard Tutorial

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    15 Apr 2014 | Teaching Materials | Contributor(s): Lisa Mahoney

    This is a short "how-to" video to familiarize users with the customizable dashboard on NCIP Hub.

  9. NCIP Hub QIN Workshop - March 3, 2015

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    19 Mar 2015 | Presentations | Contributor(s): Michael McLennan

    Mike McLennan, director of HUBzero, presented an overview of basic NCIP Hub functionality to the QIN group on March 3, 2015. The presentation included an overview of the "hub" and HUBzero, and touched upon functionality such as projects, groups, resources and information sharing. The...

  10. Next-Generation Clustered Heat Maps (NG-­CHM)

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    07 Oct 2015 | Presentations | Contributor(s): Weinstein John, Bradley Broom

    Clustered Heat Maps (CHMs) have been referred to as the ubiquitous visual icons of post-genomic biology -- the most frequent type of visualization for large molecular profiling databases. However, “traditional” CHMs are static images -- a serious limitation. Accordingly, we have now...

  11. Notes from the ITCR Annual Meeting May 27-28, 2015

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    10 Jun 2015 | Downloads | Contributor(s): Ishwar Chandramouliswaran, Juli Klemm

    Notes from the ITCR Annual Meeting May 27-28, 2015

  12. Open source diffusion MRI technology for brain cancer research

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    07 Oct 2015 | Presentations | Contributor(s): Lauren O\'Donnell

    Using measurements of water diffusion, dMRI can give unique insights into the microstructure and cellular orientation of tissues. There is a growing awareness in the neurosurgery community that diffusion models must move beyond the current clinical standard of the diffusion tensor for better...

  13. Pathology Image Informatics Platform for visualization, analysis and management

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    07 Oct 2015 | Presentations | Contributor(s): Metin Gurcan, Anant Madabhushi, Anne Martel

    This multi-institutional proposal seeks to expand on an existing, freely available pathology image viewer (Sedeen Image Viewer) to create a pathology informatics platform (PIIP) for managing, annotating, sharing, and quantitatively analyzing digital Pathology Imaging (DPI) data. Sedeen has become...

  14. Providing National Cyberinfrastructure to Biologists, esp. Genomicists

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    02 Sep 2016 | Presentations | Contributor(s): Tom Doek, Mervi Heiskanen

    National Center for Genome Analysis Support (NCGAS) provides access to High Performance Computing resources for biologists. NCGAS also maintains a curated set of applications and Galaxy instances of their software, as well as provides bioinformatics expertise.

  15. Quantitative Image Informatics for Cancer Research (QIICR)

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    04 Apr 2014 | Presentations | Contributor(s): Andrey Fedorov, Ron Kikinis

  16. Resources on NCIP Hub

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    22 Sep 2014 | Teaching Materials | Contributor(s): Lisa Mahoney

    This is a presentation given as part of the NCIP Hub Webinar Series. It reviews at a high level what resources are, why and when to use them, and how to contribute.

  17. Resources on NCIP Hub (2016)

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    02 Mar 2016 | Presentations | Contributor(s): Lisa Mahoney

    This presentation is part of NCIP Hub's 2016 Webinar Series. It provides an overview of what resources are, when and why to use resources and how to upload resources to NCIP Hub.

  18. Screening for Small Molecules: Target Discovery Against miRNAs for Breast Cancer Treatment

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    18 Aug 2015 | Presentations | Contributor(s): Odemaris Narvaez del Pilar

    Breast cancer is one of the leading causes of cancer related deaths and morbidity among women worldwide. Identifying new targets and developing new therapies is very important in order to improve patient outcomes and minimize this health burden. MicroRNAs, a type of non-coding RNA, are potential...

  19. Seven Bridges Cancer Genomics Cloud Pilot TCGA 2015 symposium workshop presentation

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    23 May 2015 | Presentations | Contributor(s): Deniz Kural

    Basic and translational cancer research creates the need to disseminate, manage, and interpret large heterogeneous datasets. The volume and complexity of the data now routinely generated by high-throughput technologies has become too costly for individual laboratories and many research...

  20. Summarization of Big Data

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    07 Nov 2014 | Presentations | Contributor(s): Jeffrey A. Blimes

    All about assay selection...