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Pathology Image Informatics Platform for visualization, analysis and management
07 Oct 2015 | Contributor(s): Metin Gurcan, Anant Madabhushi, Anne Martel
This multi-institutional proposal seeks to expand on an existing, freely available pathology image viewer (Sedeen Image Viewer) to create a pathology informatics platform (PIIP) for managing, annotating, sharing, and quantitatively analyzing digital Pathology Imaging (DPI) data. Sedeen has become...
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Next-Generation Clustered Heat Maps (NG-CHM)
07 Oct 2015 | Contributor(s): Weinstein John, Bradley Broom
Clustered Heat Maps (CHMs) have been referred to as the ubiquitous visual icons of post-genomic biology -- the most frequent type of visualization for large molecular profiling databases. However, “traditional” CHMs are static images -- a serious limitation. Accordingly, we have now...
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Open source diffusion MRI technology for brain cancer research
07 Oct 2015 | Contributor(s): Lauren O\'Donnell
Using measurements of water diffusion, dMRI can give unique insights into the microstructure and cellular orientation of tissues. There is a growing awareness in the neurosurgery community that diffusion models must move beyond the current clinical standard of the diffusion tensor for better...
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ITCR Monthly Teleconference September 4, 2015
07 Oct 2015 | Contributor(s): Juli Klemm
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Brain Cancer Imaging Analytics
02 Oct 2015 | Presentations | Contributor(s): Christos Davatzikos
The transition of oncologic imaging from its “industrial era” to it is “information era” demands analytical methods that 1) extract information from this data that is clinically and biologically relevant; 2) integrate imaging, clinical, and genomic data via rigorous...
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Screening for Small Molecules: Target Discovery Against miRNAs for Breast Cancer Treatment
18 Aug 2015 | Presentations | Contributor(s): Odemaris Narvaez del Pilar
Breast cancer is one of the leading causes of cancer related deaths and morbidity among women worldwide. Identifying new targets and developing new therapies is very important in order to improve patient outcomes and minimize this health burden. MicroRNAs, a type of non-coding RNA, are potential...
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Support Access to NPO's Structure and Content
13 Aug 2015 | Presentations | Contributor(s): Michael Halper, Vladimir Ventura, Yehoshua Perl
•Abstraction Networks (“AbNs”) for Ontologies•Two example AbNs:–Area taxonomy–Partial-area taxonomy•BLUOWL: taxonomy-based software tool•Application to the NPO•Conclusions
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A Brief History of OpenTox
25 Jun 2015 | Presentations | Contributor(s): Barry Hardy
Nano WG June 25, 2015 The history and challenges of OpenTox developments and the potential of its community, framework and principles applied to advancing safety assessment goals.
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Molecule & Particle Differentiation Using Electrophoresis
28 Apr 2015 | Presentations | Contributor(s): Frederick C. Klaessig, Sharon Ku
Nano WG April 16, 2015
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Nanoinformatics Workshop 2015
23 Mar 2015 | Presentations | Contributor(s): Mark Tuominen, Mervi Heiskanen
Nano WG March 19, 2015.
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Why in the world do we need a nanomaterials description system – How CODATA and VAMAS answers that question
12 Mar 2015 | Presentations | Contributor(s): John Rumble
Nano WG March12, 2015
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Introduction to the Trinity Cancer Transcriptome Analysis Toolkit
05 Feb 2015 | Teaching Materials | Contributor(s): Brian Haas, Aviv Regev, Bill Barnett
This short video provides an overview of our ITCR-funded effort to leverage RNA-Seq and de novo transcriptome assembly to assist researchers in studying cancer transcriptomes. Visit our NCGAS Trinity/Galaxy portal to access these compute...
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So What Can We Do With Nano Informatics? – Leveraging Decision Analytic Tools
22 Jan 2015 | Presentations | Contributor(s): Igor Linkov, Matthew Bates
Jan 22, 2015 meeting Nanotechnology Working Group Matthew E. Bates & Igor Linkov Risk & Decision Science Team Environmental Laboratory, Engineer Research and Development Center, US Army...
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Some Thoughts on Reproducibility
05 Dec 2014 | Presentations | Contributor(s): John Rumble
Nano WG December 4, 2014
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Data, Metadata and "Data Quality" for Databases
05 Dec 2014 | Presentations | Contributor(s): Frederick C. Klaessig, Mervi Heiskanen
Nano WG December 4, 2014
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Data ReproducibilityNanotechnology Knowledge Infrastructure Data Curation
05 Dec 2014 | Presentations | Contributor(s): Martin Fritts
Nano WG presentation on December 4, 2014
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LBL ICBP50 integrative genomic data
13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline
From Joe Gray, Lawrence Berkeley National Laboratory. There are seventeen (17) files in this study: Affymetrix U133A gene expression data (icbp_u133a.gct) Affymetrix U133A gene expression data (ICBP_U133a.zip) Affymetrix splice junction exon-exon data (ICBP_Junction.zip) Affymetrix...
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Baylor Residual breast cancer
13 Nov 2014 | Downloads | Contributor(s): Creighton C, Lewis M, Chang J, Jonathan Bistline
Residual breast cancers after conventional therapy display mesenchymal as tumor-initiating features. There are four (4) files included in this study: Sample Annotation (combined_sample_annotation.txt) Gene expression data from CD44+/CD24- cells sorted by flow cytometry (GSE7513.gct) Human...
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Multiclass cancer diagnosis using tumor gene expression signatures
10 Nov 2014 | Downloads
Experiment Description: The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is difficult or impossible because of atypical clinical...
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Integrated analysis of breast cancer cell lines reveals unique signaling pathways
16 Sep 2014 | Publications | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman
AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...