Integrated analysis of breast cancer cell lines reveals unique signaling pathways

16 Sep 2014 | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman

AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...

Integrative Cancer Biology Program Datasets

26 Apr 2016 | Series | Contributor(s): Jonathan Bistline, Michael Reich

The NCI-ICBP promotes an integrative/systems approach to the study of cancer biology. The Program encourages scientists to study cancer as a complex biological system. Information gained from these studies are used to build reliable and testable predictive computation models of cancer processes...

Introduction to the Trinity Cancer Transcriptome Analysis Toolkit

05 Feb 2015 | Teaching Materials | Contributor(s): Brian Haas, Aviv Regev, Bill Barnett

This short video provides an overview of our ITCR-funded effort to leverage RNA-Seq and de novo transcriptome assembly to assist researchers in studying cancer transcriptomes.  Visit our NCGAS Trinity/Galaxy portal to access these compute...

Jaqpot - An open-source web platform for creating, using, testing and sharing predictive models in nano-informatics

20 Jun 2019 | Presentations | Contributor(s): Haralambos Sarimveis

Nano WG June 20, 2019Computational models that predict physicochemical properties, biokinetics or adverse biological effects of Engineered Nanomaterials (ENMs) are becoming increasingly important to support risk assessment and safety-by-design. This is primarily due to cost-saving and...

LBL ICBP50 integrative genomic data

13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline

From Joe Gray, Lawrence Berkeley National Laboratory.  There are seventeen (17) files in this study: Affymetrix U133A gene expression data (icbp_u133a.gct) Affymetrix U133A gene expression data (ICBP_U133a.zip) Affymetrix splice junction exon-exon data (ICBP_Junction.zip) Affymetrix...

Multiclass cancer diagnosis using tumor gene expression signatures

10 Nov 2014 | Downloads

Experiment Description:    The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is difficult or impossible because of atypical clinical...

NANOANALYTICS OF EXTRACELLULAR VESICLES – Standards for isolation, characterization and reporting

26 May 2017 | Presentations | Contributor(s): Shivani Sharma

Nano WG presentation on May 25, 2017. Presentation by Dr.  Shivani Sharma, Associate Director of the Nano Pico Characterization Lab, UCLA. Nanoscale characterization of exosomes and their use disease biomarkers and drug delivery agents

NanoInformatics Knowledge Commons Curation Team: Building the Data Dictionary to Enrich Data Curation

11 Jul 2018 | Presentations | Contributor(s): Jaleesia Amos, Yuan Tian, Mervi Heiskanen

Nano WG Presentation, May 31st, 2018 Organized storing of data using informed-decision making to determine what information should be curated, when data curation is complete, and how to identify high-quality data. Purpose of NIKC structure & curation process: tell the story of...

NCI Standard CRFs

15 Mar 2014 | Teaching Materials | Contributor(s): Denise Warzel, Ann Christine Catlin, Sumudinie fernando

Working in conjunction with NCI has developed a collection of Standard Case Report Forms (CRFs) for use in developing new protocols. The project and its status are described here. The reuse of sections from standard CRFs helps to ensure that data collected in different studies is compatible and...

October 2021 CWIG Webinar Slides - Arun Isaac

27 Dec 2021 | Downloads | Contributor(s): Alan Zheng

October 2021 CWIG Webinar Slides - Pjotr Prins

27 Dec 2021 | Downloads | Contributor(s): Alan Zheng

Performance Status Scoring : a standards portal resource

15 Mar 2014 | Teaching Materials | Contributor(s): Ann Christine Catlin, Sumudinie fernando, Denise Warzel, Angela Kummerow

The scoring scale used may depend on patient population, disease, study goals and other criteria. Many definitions of the scale scoring do not match the standard.What is Performance Status?Performance status attempts to quantify the general well-being of cancer and other patients. The score...

Screening for Small Molecules: Target Discovery Against miRNAs for Breast Cancer Treatment

18 Aug 2015 | Presentations | Contributor(s): Odemaris Narvaez del Pilar

Breast cancer is one of the leading causes of cancer related deaths and morbidity among women worldwide. Identifying new targets and developing new therapies is very important in order to improve patient outcomes and minimize this health burden. MicroRNAs, a type of non-coding RNA, are potential...

September 2021 CWIG Webinar Slides - Junjun Zhang

27 Dec 2021 | Presentations | Contributor(s): Alan Zheng

Standards Portal CDEs Complete View

15 Mar 2014 | Teaching Materials | Contributor(s): Denise Warzel, Ann Christine Catlin, Sumudinie fernando

This DataView on this resource page is used to explore the Standards Portal CDEsUse the DataView provided on this resource page to navigate, browse, search, explore and download the complete set of columns for NCI common data elements standards at the Hub. These CDEs are brought to the Hub for...

Standards Portal CRFs Common Data Fields

19 Mar 2014 | Downloads | Contributor(s): Denise Warzel, Sumudinie fernando, Ann Christine Catlin

This DataView is for the Common Data Fields of the Standards Portal CRFsUse this DataView to browse, search, explore and download the essential set of columns for NCI case report form standards at the Hub. These CRFs were brought to the Hub for clarification, discussion and discovery. They were...

Standards Portal CRFs Complete View

19 Mar 2014 | Downloads | Contributor(s): Denise Warzel, Sumudinie fernando, Ann Christine Catlin

This DataView resource page is for the Standards Portal CRFsUse this DataView to browse,search, explore and download the complete set of columns for NCI case report form standards at the Hub. These CRFs were brought to the Hub for clarification, discussion and discovery. They were assembled by...

Standards Portal Vocabulary DataView

15 Mar 2014 | Teaching Materials | Contributor(s): Sherri de Coronado, Denise Warzel, Ann Christine Catlin, Sumudinie fernando

The DataView for terminology referenced/used by the CDEs and CRFs currently contained in the Standards PortalThe DataView on this resource page can be used to browse, search, explore and download the NCI concepts for vocabulary referenced by the CDEs and CRFs uploaded to the Standards Portal....

Summary of the 2015 Epigenetic Engineering for Cancer Workshops

22 Dec 2015 | Publications | Contributor(s): Tony Dickherber

This document provides a general summary of the 2 virtual workshops held in Fall of 2015 to explore the suitability of epigenetic engineering tools to specifically modify epigenetic loci to study and/or treat cancer.