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Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology (NanoSolveIT)
04 Feb 2019 | Contributor(s): Antreas Afantitis
Nano WG January 17, 2019NanoSolveIT (a new H2020 nanoinformatics project) aspires to introduce a ground-breaking in silico Integrated Approach to Testing and Assessment (IATA) for the environmental health and safety of Nanomaterials (NM), implemented through a decision support system packaged...
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Integrated analysis of breast cancer cell lines reveals unique signaling pathways
16 Sep 2014 | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman
AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...
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Integrative Cancer Biology Program Datasets
26 Apr 2016 | Series | Contributor(s): Jonathan Bistline, Michael Reich
The NCI-ICBP promotes an integrative/systems approach to the study of cancer biology. The Program encourages scientists to study cancer as a complex biological system. Information gained from these studies are used to build reliable and testable predictive computation models of cancer processes...
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Introduction to the Trinity Cancer Transcriptome Analysis Toolkit
05 Feb 2015 | Teaching Materials | Contributor(s): Brian Haas, Aviv Regev, Bill Barnett
This short video provides an overview of our ITCR-funded effort to leverage RNA-Seq and de novo transcriptome assembly to assist researchers in studying cancer transcriptomes. Visit our NCGAS Trinity/Galaxy portal to access these compute...
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ISA-TAB-Nano 1.3 release review
09 Mar 2020 | Presentations | Contributor(s): Mervi Heiskanen, Mervi Anneli Heiskanen
Nano WG January 30th, 2020Review of the new 1.3 release with the Nano WG
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ISA-TAB-Nano-Expanded: Community-Sourced Updated Templates
22 Sep 2017 | Presentations | Contributor(s): Nancy Birkner
Nano WG Presentation September 21, 2017 by Nancy Birkner, Duke University. ISA-TAB-Nano extension project with added support for environmental, health and safety assessment of nanomaterials. Center for the Environmental Implications of Nanotechnology (CEINT) took on the leadership of...
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Jaqpot - An open-source web platform for creating, using, testing and sharing predictive models in nano-informatics
20 Jun 2019 | Presentations | Contributor(s): Haralambos Sarimveis
Nano WG June 20, 2019Computational models that predict physicochemical properties, biokinetics or adverse biological effects of Engineered Nanomaterials (ENMs) are becoming increasingly important to support risk assessment and safety-by-design. This is primarily due to cost-saving and...
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LBL ICBP50 integrative genomic data
13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline
From Joe Gray, Lawrence Berkeley National Laboratory. There are seventeen (17) files in this study: Affymetrix U133A gene expression data (icbp_u133a.gct) Affymetrix U133A gene expression data (ICBP_U133a.zip) Affymetrix splice junction exon-exon data (ICBP_Junction.zip) Affymetrix...
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Multiclass cancer diagnosis using tumor gene expression signatures
10 Nov 2014 | Downloads
Experiment Description: The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is difficult or impossible because of atypical clinical...
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nano-Ag: PBTK Models, Vblood & NIOSH
04 Feb 2019 | Presentations | Contributor(s): Frederick C. Klaessig, Mervi Heiskanen
Nano WG: January 31, 2019Nanoinformatics and computational models1.Examine a nano-Ag0 computational model used in a regulatory context2.SCCS has a nano-silver opinion3.NIOSH time period overlaps with the nanoinformatics roadmap4.NIOSH a case study for roadmap’s...
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NANOANALYTICS OF EXTRACELLULAR VESICLES – Standards for isolation, characterization and reporting
26 May 2017 | Presentations | Contributor(s): Shivani Sharma
Nano WG presentation on May 25, 2017. Presentation by Dr. Shivani Sharma, Associate Director of the Nano Pico Characterization Lab, UCLA. Nanoscale characterization of exosomes and their use disease biomarkers and drug delivery agents
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Nanocuration update by Christine Hendren
02 Jun 2014 | Presentations | Contributor(s): Christine Ogilvie Hendren
Nanocuration update by Christine Hendren, Nano WG May 29, 2014
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NanoInformatics Knowledge Commons Curation Team: Building the Data Dictionary to Enrich Data Curation
11 Jul 2018 | Presentations | Contributor(s): Jaleesia Amos, Yuan Tian, Mervi Heiskanen
Nano WG Presentation, May 31st, 2018 Organized storing of data using informed-decision making to determine what information should be curated, when data curation is complete, and how to identify high-quality data. Purpose of NIKC structure & curation process: tell the story of...
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Nanomaterials & Scientific Committee on Consumer Safety: Overview with Focus on nano-hydroxyapatite and Silica
23 Jan 2020 | Presentations | Contributor(s): Frederick C. Klaessig
Nano WG January 23, 2020The EU’s Scientific Committee on Consumer Safety advises the European Commission on the safety of products covered by the Cosmetics Directive, which includes personal care products as well as cosmetics. In the 2013-2016 time period, the Committee published...
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NANoREG-Proposed ISA-TAB-Nano Template Expansion
13 Apr 2017 | Presentations | Contributor(s): Nancy Birkner
Nano WG presentation April 13, 2017 by Dr. Nancy Birkner, post-doctoral associate at Duke University working in conjunction with the NanoInformatics Knowledge Commons, presented her progress on reviewing and updating the ISA-TAB-Nano data exchange formats. Dr. Birkner described the evolution of...
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NCI Alliance for Nanotechnology in Cancer, and caNanoLab: A Data Repository for Cancer Nanomedicines
27 Nov 2018 | Presentations | Contributor(s): Luisa Russell, Mervi Heiskanen
Nano WG presentation November15, 2018 NCI Alliance for Nanotechnology in Cancer –Structure–Achievements–Scientific FocuscaNanoLab–Intro to Platform–Data Curation–User Statistics–Future Directions
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Overview of the National Cancer Institute (NCI) Nanotechnology Characterizaton Laboratory (NCL)
03 Nov 2014 | Presentations | Contributor(s): Jennifer Hall Grossman
Working in concert with the National Institute of Standards and Technology (NIST) and the U.S. Food and Drug Administration (FDA), the National Cancer Institute (NCI) established the Nanotechnology Characterization Laboratory to perform preclinical efficacy and toxicity testing of...
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Read across in nanosafety research: Dissolution behaviour of a library of 37 nanomaterials in simplified physiological media
05 Nov 2019 | Presentations | Contributor(s): Tassos Papadiamantis, Emily Guggenheim, Antreas Afantitis, Sophie Briffa, Georgia Melagraki, Iseult Lynch, Eugenia Valsami-Jones
NanoWorkingGroup, 31 October 2019The dissolution of engineered nanomaterials (ENMs) is a complex process, which remains poorly understood despite being one of the key prerequisites for the risk assessment of ENMs, and having a direct influence on toxicological and eco-toxicological effects....
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Screening for Small Molecules: Target Discovery Against miRNAs for Breast Cancer Treatment
18 Aug 2015 | Presentations | Contributor(s): Odemaris Narvaez del Pilar
Breast cancer is one of the leading causes of cancer related deaths and morbidity among women worldwide. Identifying new targets and developing new therapies is very important in order to improve patient outcomes and minimize this health burden. MicroRNAs, a type of non-coding RNA, are potential...
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Some thoughts on our progress in defining and advancing nanoinformatics
06 Nov 2018 | Presentations | Contributor(s): Mark D Hoover
Nano WG presentation November 1, 2018 by Mark Hoover, NIOSH Discussion on Nano WG accomplishments, goals and future directions.