Screening for Small Molecules: Target Discovery Against miRNAs for Breast Cancer Treatment
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18 Aug 2015 | Contributor(s):: Odemaris Narvaez del Pilar
Breast cancer is one of the leading causes of cancer related deaths and morbidity among women worldwide. Identifying new targets and developing new therapies is very important in order to improve patient outcomes and minimize this health burden. MicroRNAs, a type of non-coding RNA, are potential...
Drug Selection of γδ T cells using miRNA target sequences
18 Aug 2015 | Contributor(s):: Rosa Maria Santana Carrero
Gamma delta T cells constitute a small subset of circulating T lymphocytes in peripheral blood, and recognize antigens in an MHC-independent manner through their γδ T cell receptor. We sought to selectively expand ablatable γδ T cells using an inducible suicide switch,...