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  1. Integrated analysis of breast cancer cell lines reveals unique signaling pathways

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    16 Sep 2014 | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman

    AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...

  2. Informatics to enable Routine Personalized Cancer Therapy (IPCT)

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    18 Feb 2014 | Contributor(s): Elmer V. Bernstam, Funda Meric-Bernstam

  3. Advanced Development of TIES - A Clinical Text Search Engine

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    18 Feb 2014 | Contributor(s): Rebecca Crowley

    Archived human tissues are an essential resource for translational research. Formalin-fixed, paraffin-embedded (FFPE) tissues from cancer patients are used in a wide range of assays, including RT-PCR, SNP profiling, multiplex biomarkers, imaging biomarkers, targeted exome, whole exome, and whole...

  4. Informatics Tools for High-throughput Analysis of Cancer Mutations

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    15 Jan 2014 | Contributor(s): Michael C Ryan, Rachel Karchin

  5. caNanoLab: data sharing to expedite the use of nanotechnology in biomedicine

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    13 Dec 2013 | Publications | Contributor(s): Sharon Gaheen, George W Hinkal, Stephanie A Morris, Michal Lijowski, Mervi Heiskanen, Juli Klemm

    The use of nanotechnology in biomedicine involves the engineering of nanomaterials to act as therapeutic carriers, targeting agents and diagnostic imaging devices. The application of nanotechnology in cancer aims to transform early detection, targeted therapeutics and cancer prevention and...