Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May Be Clinically Relevant? Pancreatic Neoplasms
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Bernard V, Fleming J, Maitra A. Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May Be Clinically Relevant? Pancreatic Neoplasms. Surgical Oncology Clinics of North America. Vol. 25 Iss 2, April 2016. PubMed PMID: 27013361
Carcinogenic progression in the pancreas arises through a well-established stepwise accumulation of molecular aberrations from a normal cell to an invasive adenocarcinoma. Recent large-scale sequencing efforts have provided insight into novel driver genes as well as enriched core signaling pathways that underlie the inherent heterogeneity found in pancreatic cancer. By exploiting these genomic profiles, we may begin to provide new insights into patient stratification and therapeutic guidance. This review discusses the molecular landscape of pancreatic cancer and its role in tumor progression, clinical prognostication, and the development of novel therapeutic strategies.
Acknowledgments
This work was supported by the Cancer Prevention Research Institute of Texas [RP140106 to V.B.].
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The University of Texas MD Anderson Cancer Center