Skip to main content
The NCI Community Hub will be retiring in May 2024. For more information please visit the NCIHub Retirement Page:https://ncihub.cancer.gov/groups/ncihubshutdown/overview
close
The profile picture for Andries Zijlstra

Andries Zijlstra

►

Profile

Profile

  • Organization
    Vanderbilt University

  • Use Statement - Please enter your reason for creating an NCI Hub account.
    (not set)

  • Website
    https://my.vanderbilt.edu/zijlstra/

  • Reason
    (not set)

  • Interests
    1. cancer biology
    2. cancer models
    3. cell migration
    4. clinical translation
    5. metastasis
    6. molecular barcoding
    7. skeletal metastasis

  • Biography

     



    TITLE AND AFFILIATION:



     



    Primary Appointment:  



                    Assistant Professor



                    Department of Pathology Microbiology and Immunology



                    Vanderbilt University School of Medicine



        



    Dual Appointment:    



                    Assistant Professor



                    Department of Cancer Biology



                    Vanderbilt University School of Medicine



     



    EDUCATION



     



    1989-1991    A.S. in Biology



        Centralia Community College, Centralia, WA



     



    1991-1993    B.S. in Molecular Biology, Genetics and Cell Biology



        Washington State University, Pullman, WA



     



    1993-1998    Ph.D. Genetics and Cell Biology



        Washington State University, Pullman, WA



     



    1998-2000    Research Fellow, Laboratory of Cell Biology



        National Institute for Cancer Research, Italy (IST)



        Genova Italy



     



    2000-2006    Senior Research Associate, Department of Cell Biology



        The Scripps Research Institute



        La Jolla, CA



     



     



    PRINCIPAL POSITIONS HELD



     



    2006- current    Assistant Professor, Department of Pathology, Microbiology and Immunology.



        Vanderbilt University Medical Center, Nashville, TN 



    2006- current     Assistant Professor, Department of Cancer Biology



        Vanderbilt University Medical Center,  Nashville, TN



    2006- current    Faculty Member - Vanderbilt-Ingram Cancer Center (VICC)



        Division of Host-Tumor Interactions



    2008- current    Faculty Member - Vanderbilt Center for Bone Biology (VCBB)



    2008- current    Faculty Member - Vanderbilt Institute for Integrative Biosystem Research and Education (VIIBRE)



     



     



    PUBLICATIONS



     



    First or Corresponding Author Publications




    1. Andries Zijlstra and Margaret Schelling. (1999) Detection of multiple fibronectin isoforms in fetal fibroblast monolayer culture: a novel method for the qualitative and quantitative detection of multiple antigens. Histochem. Cell Biol., Feb;111(2):163-9. 

    2. Andries Zijlstra, Norah McCabe, Margaret Schelling. (1999) Expression and Assembly of the Angiogenic Marker B-Fibronectin by Endothelial Cells In Vitro: Regulation by Confluency. Angiogenesis, 3: 77-87.

    3. Andries Zijlstra, Rebecca Mellor, Giano Panzarella, Ronald T. Aimes, John D. Hooper, Natalia D. Marchenko, and James P. Quigley. (2002) A Quantitative Analysis of Rate Limiting Steps in the Metastatic Cascade using human specific real-time PCR. Cancer Research, 62: 7083-7092. (PMID: 12460930)

    4. John D. Hooper*, Andries Zijlstra*, Ronald T. Aimes*, Hongyan Liang, Gisela F. Claassen, Jacqueline E. Testa, David Tarin and James P. Quigley. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA-135/CDCP1, a 135kDa Cell surface phosphorylated glycoprotein antigen. Oncogene, 22: 1783-1794.

    5. Ronald T. Aimes*, Andries Zijlstra*, John D. Hooper*, Steven M. Ogbourne, Mae-le Sit, Simone Fuchs, David C. Gotley, James P. Quigley, and Toni M. Antalis. (2003) Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thrombosis and Haemostasis, 89: 561-72.

    6. Andries Zijlstra*, Ronald T. Aimes*, Dan Zhu, Karine Regazzoni, Marco Seandel, Elena I. Deryugina and James P. Quigley. (2004) Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). Journal of Biological Chemistry, 279(26): 27633-45. (PMID: 15066996)

    7. Elena I. Deryugina*, Andries Zijlstra*, Junith Partridge, Tatyana A. Kupriyanova, Mark Madson, Thales Papagiannakopoulos, and James P. Quigley. (2005) Unexpected Effect of Matrix Metalloproteinase Downregulation on Vascular Intravasation and Metastasis of Human Fibrosarcoma Cells selected in vivo for High Rates of Dissemination. Cancer Research Dec 1;65(23):10959-69. (PMID: 16322244)

    8. Andries Zijlstra, Marco Seandal, Elisabeth A. Hahn-Dantona, Tatyana Kupriyanova, Juneth Partridge, James P. Quigley and Elena I. Deryugina. (2006) Pro-angiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Blood, Jan 1;107 (1):317-27. (PMID: 16174763)

    9. Andries Zijlstra and James P. Quigley (2006) The DARC side of metastasis: shining a light on KAI1-mediated metastasis suppression in the vascular tunnel. Cancer Cell Sept (10), 177-178. (PMID: 16959609)

    10. Andries Zijlstra, John Lewis, Bernard DeGryse, Heidi Stuhlmann, and James P. Quigley (2008) The inhibition of tumor cell intravasation and subsequent metastasis through the regulation of in vivo tumor cell motility by the tetraspanin CD151, Cancer Cell, March 13 (3) pp. 221-34. (PMID: 18328426)

    11. Trenis Palmer and Andries Zijlstra (2011) CD151. UCSD-Nature Molecule Pages (doi:10.1038/mp.a004123.01)

    12. Amanda G. Hansen, Guido W. Swart, and Andries Zijlstra (2011) ALCAM. UCSD-Nature Molecule Pages (doi:10.1038/mp.a004126.01) 

    13. Trenis D. Palmer, John D. Lewis, and Andries Zijlstra (2011) Quantitative analysis of cancer metastasis using an avian embryo model. Journal of visualized experiments : JoVE, (51), e2815. (PMID: 21673636)

    14. Trenis D. Palmer, William Ashby, John D. Lewis, and Andries Zijlstra (2011) Targeting Tumor Cell Motility and Metastasis. Advanced Drug Delivery Reviews, 63(8), 568–581. (PMID: 21664937)

    15. William J. Ashby and Andries Zijlstra (2012) Established and Novel Methods of Interrogating Two-Dimensional Cell Migration. Integrative Biology 4(11):1338–1350. PMID: 23038152

    16. William J. Ashby, John P. Wikswo, Andries Zijlstra (2012) Magnetically attachable stencils and the non-destructive analysis of the contribution made by the underlying matrix to cell migration. Biomaterials, 33(33), 8189–8203. PMID: 22940214/PMCID: PMC3444626 

    17. Amanda G. Hansen, Tanner J. Freeman, Shanna A. Arnold, Alina  Starchenko, Celestial R. Jones-Paris, Michael A. Gilger, Mary K. Washington, Kang-Hsien Fan, Yu Shyr, Robert D. Beauchamp and Andries Zijlstra. (2013) Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome. Cancer Research 73(10): 2955–2964. (doi: 10.1158/0008-5472.CAN-12-2052) PMID: 23539446/PMCID: PMC3660148 

    18. William J. Ashby, John P. Wikswo, and Andries Zijlstra (2013) Magnetically Attachable Templates: Taking the Punch Out of PDMS Microfluidic Interconnects. The Open Biomedical Engineering Journal (accepted)

    19. Trenis D. Palmer, Carlos H. Martínez, Catalina Vasquez, Celestial R. Jones-Paris, Katie Hebron, Susanne M. Chan, Venu Chalasani, Jose A. Gomez-Lemus, Andrew K. Williams, Joseph L. Chin, Tatiana Ketova, John D. Lewis and Andries Zijlstra (2013) Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression.  Cancer Research 74(1): 173-187. PMID:24220242/PMCID: in progress

    20. Amanda G. Hansen, Shanna Arnold, Trenis D. Palmer, Tatiana Ketova, Alyssa Merkel, Michael Pickup, J. Preston Campbell, Jiang Ming, Harold L. Moses, Simon Hayward, Julie A. Sterling, and Andries Zijlstra (2014) ALCAM/CD166 is a TGFβ responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Research  PMID: 24385212



     



     



     



     



    Contributing Author Publications



    ​




    1. E. Balza, P. Castellani, A. Zijlstra, D. Neri, L. Zardi, A. Siri. (2001) Lack of specificity of endoglin expression for tumor blood vessels. International J. of Cancer, 94(4): 579-85. (PMID: 11745447)

    2. Susan Wilson, Brett Greer, John Hooper, Andries Zijlstra, James P. Quigley, Susan Hawthorn. (2005) The membrane-anchored serine protease TMPRSS-2 activates PAR-2 in prostate cancer cells. Biochem. J., 399(3) 967-972 (PMID: 15537383/PMCID: PMC1183478)

    3. Pilar Blancafort, Emily Chen, Beatriz Gonzalez, Sharon Bergquist, Andries Zijlstra, James P. Quigley, Caren V. Lund, Ruud Brakenhoff, Dirk Edrmann and Carlos F. Barbas III. (2005) Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci USA, 102(33):11716-21 (PMID:16081541/PMCID: PMC1187960 )

    4. Lewis, J.D., Destito, G., Zijlstra, A., Gonzalez, M.J., Quigley, J.P., Manchester, M., and Stuhlmann, H. (2006). Viral nanoparticles as tools for intravital vascular imaging. Nature Med., March vol. 12 (3) pp. 354-60. (PMID: 16501571/PMCID: PMC2536493)

    5. Chloe Feral, Andries Zijlstra, Gerald Prager, Marina Slepak, Mark H. Ginsberg (2007) CD98hc (SLC3A2) Mediates Fibronectin Matrix Assembly, JCB, Aug 13;178(4):701-11. (PMID: 17682053/PMCID: PMC2064475)

    6. Choi-Fong Cho, Amber Ablack, Hon-Sing Leong, Andries Zijlstra, and John Lewis. (2011) Evaluation of nanoparticle uptake in tumors in real time using intravital imaging. Journal of visualized experiments : JoVE, (52), e2808. (PMID: 21730939/PMCID: PMC3197055)

    7. Hon Sing Leong, Nicole F. Steinmetz, Amber Ablack, Giuseppe Destito, Andries Zijlstra, Heidi Stuhlmann, Marianne Manchester, John D. Lewis (2010) Viral nanoparticles as a platform for intravital imaging of embryonic and tumor neovasculature. Nature Protocols, 5, 1406–1417 (PMID: 20671724/PMCID: PMC3163450)

    8. Norma E. Ramirez, Zhonghua Zhang, Aasakiran Madamanchi, Kelli L. Boyd, Lynda D. O’Rear, Abudi Nashabi, Zhengzi Li, William D. Dupont, Andries Zijlstra, and Mary M. Zutter. (2010) The α2β1 integrin is a metastasis suppressor in mouse models and human cancer. Journal of Clinical Investigations, Jan;121(1):226-37  (PMID: 21135504/PMCID: PMC3007139)

    9. Yi Zhang, Wendy Schulte, Desmond Pink, Andries Zijlstra, John Lewis, and David Morton Waisman (2010) Sensitivity of Cancer Cells to Truncated Diphtheria Toxin. PLOS ONE, 5(5):e10498. (PMID: 20463924/PMCID: PMC2864767)

    10. Yandong Gao, Devi Majumdar, Bojana Jovanovic, Candice Shaifer, P. Charles Lin, Andries Zijlstra, Donna J. Webb, and Deyu Li. (2011) A Versatile Valve-Enabled Microfluidic Cell Co-Culture Platform and Demonstration of its Applications to Neurobiology and Cancer Biology. Biomedical Microdevices, 13(3), 539–548. (PMID: 21424383/PMCID: PMC3085600)

    11. Desmond B.S. Pink, Wendy Schulte, Missag H. Parseghian, Andries Zijlstra, John D. Lewis (2012) Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery. PLoS ONE 7(3): e33760. (PMID: 22479438/PMCID: PMC3315578)

    12. AJ. Preston Campbell, Matthew R. Karolak, Yun Ma, Daniel S. Perrien, S. Kathryn Masood-Campbell, Steve A. Munoz, Andries Zijlstra, Xiangli Yang, Julie A. Sterling and Florent Elefteriou. (2012) Activation of Sympathetic Nerves in Mice Promotes Breast Cancer Bone Metastasis via RANKL. PLOS Biology, 10(7), e1001363. (PMID: 22815651/PMCID: PMC3398959)

    13. Lauren A. Matise, Trenis D. Palmer, William J. Ashby, Abudi Nashabi, Anna Chytil, Mary Aakre, Michael W. Pickup, Andries Zijlstra and Harold L. Moses. (2012) Lack of TGF-β signaling promotes collective cancer cell invasion in tumor-stromal crosstalk. Breast Cancer Research, 14(4), R98. (PMID: 22748014/PMCID: PMC3680921



     



     



     



    Invited Reviews, Commentaries and Book Chapters



     



     




    1. Andries Zijlstra, Jacqueline E. Testa, and James P. Quigley. (2003) Targeting the proteome/epitome, implementation of subtractive immunization. Biochemical and Biophysical Research Communications, 303: 733-744. (PMID:12670472)

    2. Zijlstra, A., Mikolon D.M. and D.G. Stupack. (2007) Angiogenesis Assays in the Chick.  In: Angiogenesis Assays: a critical appraisal of current techniques. Eds: Staton CA, Lewis CE, Bicknell R. John Wiley & Sons. 

    3. Andries Zijlstra (2009) Launching and Academic Research Career. Dis Model Mech. 2009 Nov-Dec;2(11-12):526-30. 

    4. Andries Zijlstra (2009) Tetraspanins in Cancer. In: Cell-Extracellular Matrix Interactions in Cancer. Ed. Zent, R and Pozzi, A. Springer Science and Business Media 

    5. Andries Zijlstra and John D. Lewis. (2012) Visualization and quantification of de novo angiogenesis in ex ovo chicken embryos. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. (eds. Zudaire, E. and Cuttitta, F. Dordrecht: Springer Netherlands.

    6. Michael W. Irvin, Andries Zijlstra, John P. Wikswo, and Ambra Pozzi. (2014) Techniques and assays for the study of angiogenesis. Experimental Biology and Medicine  (EBM_Angiogenesis_1309-MR-368R1in press)

    7. Kristin H. Kain, James W.I. Miller, Celestial R. Jones-Paris, Rebecca T. Thomason, John D. Lewis, David M. Bader, Joey V. Barnett and Andries Zijlstra (2014) The chick embryo as an expanding experimental model for cancer and cardiovascular research. Developmental Dynamics. 243(2): 216-228. (PMID:24357262)

    8. Konstantin Stoletov, David Bond, Katie Hebron, Srijan Raha, Andries Zijlstra and John D. Lewis (2014) Metastasis as a therapeutic target: a conceptual framework. American Journal of Clinical and Experimental Urology. In Press

    9. A. Madamanchi, A. Zijlstra, M. M. Zutter (2014) Flipping the Switch: Integrin Switching Provides Metastatic Competence. Sci. Signal. 7, pe9 (PMID:24667375)