ADVANCED DEVELOPMENT AND VALIDATION OF TARGETED MOLECULAR COUNTING METHODS FOR PRECISE AND ULTRASENSITIVE QUANTITATION OF LOW PREVALENCE SOMATIC MUTATIONS

SYSTEMATIC AND COMPREHENSIVE SAMPLING OF PEPTIDES IN MIXTURES BY TANDEM MASS SPECTROMETRY

SENSOR-SEQ: A GENOME-WIDE BIOLOGICAL MEASURE OF MICRORNA ACTIVITY.

DEVELOPMENT OF MASSSQUIRM TO QUANTITATIVELY MEASURE LYSINE METHYLATION

WHOLE GENOME AMPLIFICATION AND SEQUENCING OF SINGLE CANCER CELLS

SCALABLE CANCER GENOMICS VIA NANOCODING AND SEQUENCING

KINASE BINDING FLUORESCENT PROBES FOR ASSAYING CELLULAR RECEPTOR POPULATIONS

KINASE PROFILING WITH QUANTITITATIVE CHEMOPROTEOMICS

MULTIPLEXED KINASE BIOSENSOR TECHNOLOGY TO DETECT LEUKEMIA SIGNALING WITH MASS SPECTROMETRY

AN OPTIMIZED DESIGN FOR SINGLE COPY SHORT HAIRPIN RNAI

A NOVEL ALLELE-SPECIFIC RNA-ISH FOR DIFFERENTIAL ALLELE-SPECIFIC EXPRESSION

PROTEIN PAINTING REVEALS HIDDEN PROTEIN-PROTEIN INTERACTION DOMAINS

It is well appreciated that cancer is a complex disease accounted for by cellular dysfunction. It is further well appreciated that the multiple molecular pathways involved in the hundreds of conditions collectively called cancer are at the heart of this complexity. The ability to explore and understand the interaction of nucleic acids and proteins will be critical for offering patients improved diagnosis and treatment for their conditions. In order to achieve this, an integration of various molecular profiling technologies (e.g. genomic, proteomic, metabolomics, etc) and the data management and processing tools that will facilitate this will be required. The IMAT and ITCR programs support a variety of technology development projects likely to contribute to this potential. This project site is intended to facilitate broad awareness of relevant projects and catalyze collaborations between complementary groups.