High-performance computing has become central to the future success of precision medicine. The dramatic increase in the volume of research and clinical data available through medical records, imaging technologies, sequencing, biometric sensors, and mobile health devices, has also opened many new frontiers for AI in medicine.  Powered new computing platforms from edge to exascale, there is a critical convergence where HPC is shaping the future for medicine, from cancer to infectious diseases, to drug discovery, to digital twins, to critical decisions in hospital intensive care units. This workshop series is held in conjunction with the ISC High Performance Conference.