HTT Data Collection Training CME
- Version 20
- by (unknown)
- Version 21
- by (unknown)
Deletions or items before changed
Additions or items after changed
| 1 | [HTTdataCollectionTraining Top node for HTT training] | |||
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| 2 | ||||
| 3 | ="Mirror" of CME Course: Assessment of Stromal Tumor-Infiltrating Lymphocytes= | |||
| 4 | Information about the official CME course and obtaining CME credits can be found here: [HTTDataCollectionTraining LINK]. | |||
| 5 | ||||
| 6 | =Description= | |||
| 7 | Tumor-infiltrating lymphocytes have been established as a prognostic biomarker in early-stage triple negative breast cancer. The assessment of the density of stromal tumor-infiltrating lymphocytes at the time of diagnosis may improve the accuracy of prognosis determination and inform therapeutic decision-making. | |||
| 8 | ||||
| 9 | =Learning Objectives= | |||
| 10 | After completing the module, the participant should be able to: | |||
| 11 | # Describe the significance of stromal tumor infiltrating lymphocytes in triple negative breast cancer. [[BR]] | |||
| 12 | # Demonstrate knowledge of the approach to determining the density of stromal tumor infiltrating lymphocytes. [[BR]] | |||
| 13 | ||||
| 14 | =Target Audience= | |||
| 15 | Physicians | |||
| 16 | ||||
| 17 | ||||
| 18 | == Course Content (3.00 CME credits)== | |||
| 19 | ---- | |||
| 20 | =1. Introduction to stromal tumor-infiltrating lymphocytes ''(12min presentation)''= | |||
| 21 | * We discuss the immune systems' role in mediating tumor progression, and the statistics and literature that demonstrate how sTILs are prognostic biomarkers for patient outcomes and response to therapy in certain types of breast cancer. | |||
| 22 | * [https://vimeo.com/800001397 Watch the video here] | |||
| 23 | ||||
| 24 | =2. TILs Education: What are TILs and their Assessment ''(8min tutorial video)''= | |||
| 25 | * Video description of the steps of the sTILs assessment. | |||
| 26 | * Presented by the International TILs Working Group | |||
| 27 | [[Video(https://www.youtube.com/watch?v=aPa-pXIBBlU)]] | |||
| 28 | ||||
| 29 | =3. Pitfalls in the sTILs Assessment ''(27min presentation)''= | |||
| 30 | * Discussion of example pitfalls encountered in the sTILs assessment. | |||
| 31 | * [https://vimeo.com/799870097 Watch the video here] | |||
| 32 | ||||
| 33 | =4. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 ''(30min publication)''= | |||
| 34 | * [[File(Salgado2015_Annals-of-Oncology_v26p259.pdf)]] | |||
| 35 | * Salgado R, Denkert C, Demaria S, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S, Willard-Gallo K, Loi S; International TILs Working Group 2014. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol. 2015 Feb;26(2):259-71. https://doi.org/10.1093/annonc/mdu450. Epub 2014 Sep 11. PMID: 25214542; PMCID: PMC6267863. | |||
| 36 | ||||
| 37 | =5. Post-Course Assessment= | |||
| 38 | * Complete the post-course assessment. | |||
| 39 | ||||
| 40 | ||||
| 41 | = Additional Information= | |||
| 42 | * [https://ncihub.cancer.gov/groups/eedapstudies/wiki/HTTDataCollectionTrainingCME/Image:sTILs-CheatSheet-Figure4.jpg sTILs-CheatSheet-Figure4]: Salgado et al. (2015) created a visual reference sheet to help users calibrate their sTILs assessments (https://doi.org/10.1093/annonc/mdu450). | |||
| 43 | ||||
| 44 | * sTILs-Reference-Document: [[File(sTIL_reference_document_combined-20221026.pdf)]] | |||
| 45 | ||||
| 46 | * Presentation slides for the videos: [[File(cmeCourseSlides-combined-final-20230217.pdf)]] | |||
| 47 | ||||
| 48 | - | * Additional '''interactive training''' on sTILs assessment is available |
+ | * Additional '''interactive training''' on sTILs assessment is available here: [HTTDataCollectionTrainingInteractive LINK]
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| 49 | ||||
| 50 | * For more information on the research project in which this course was developed (the High-Throughput Truthing project), please visit [https://ncihub.cancer.gov/groups/eedapstudies] | |||
| 51 | ||||
| 52 | * For more information on the sTILs assessment and to get involved with the International Immuno-Oncology Biomarker Working Group on Breast Cancer (the International TILS Working Group), please visit [https://www.tilsinbreastcancer.org/] | |||
| 53 | ||||
| 54 | * This work was supported by the FDA Office of Women's Health. This project was supported in part by an appointment to the ORISE Research Participation Program at the Center for Drugs and Radiological Health, U.S. Food and Drug Administration, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and FDA/Center. We also acknowledge the Pathology Department of Institut Jules Bordet in Brussels, Belgium for providing the pathology slides for this work. | |||
| 55 | ||||
| 56 | * References from the 'Activity Announcement with Additional Details' section of the CME course: | |||
| 57 | * Kos, Z. et al. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer. npj Breast Cancer 6, 17 (2020). https://www.doi.org/10.1038/s41523-020-0156-0 | |||
| 58 | * [https://www.tilsinbreastcancer.org/what-are-tils/ What are TILs and why are they important?] | |||
| 59 | ||||
| 60 | ||||
| 61 | ||||
| 62 | ==The HTT Pivotal Study== | |||
| 63 | ---- | |||
| 64 | * If you would like to proceed with collecting annotations for the HTT project's pivotal study, please email your completion certificate to Brandon Gallas (brandon.gallas@fda.hhs.gov). | |||