The NCI initiated the Co-Clinical Imaging Research Resource Program (CIRP) in 2015 to establish web-accessible, co-clinical, quantitative imaging research resources funded under several program announcements, i.e., PAR-18-841. The CIRP supports ten co-clinical trial projects spanning a diverse range of tumor types, therapeutic interventions, and imaging modalities. Each CIRP resource contains four essential components: animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative preclinical and clinical imaging methods, and informatics for supporting web resources. The deliverable of a CIRP-funded project is a web resource populated with all the methodologies, protocols, tools, and data associated with quantitative imaging in preclinical and clinical trial settings by the end of year 5.
The CIRP network includes a steering committee, CIRP teams, working groups, and associate members. The network's mission is to advance the practice of precision medicine by establishing consensus-based best practices for co-clinical imaging and by developing optimized state-of-the-art quantitative imaging methodologies for disease detection, risk stratification, and therapeutic response assessment.
The NCI CIRP program awarded ten 5-year projects between 2017-2022. These projects focus on seven adult and one pediatric cancer, including breast, bone, colon, hematology, lung, muscle, pancreas, and prostate cancers.
The CIRP network has three working groups (WGs), including Animal Models and Co-Clinical trials (AMCT) WG, Imaging Acquisition and Data Process (IADP) WG, and InforMatics and OutReach (IMOR) WG.
All CIRP projects have launched a website for their web resources. A list of data collection items and the hyperlink to access these web resources are available. In addition, resources are provided by CIRP associate members.
Academic investigators with expertise in animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative imaging in the preclinical and clinical settings, and state-of-art informatics join the CIRP WGs.
CIRP holds annual meetings and organizes meeting sessions at scientific conferences and meetings by other NCI programs. CIRP annual meeting is open to the public, and there is no registration fee for attending the meeting.
The CIRP network invites NCI and NIH-supported academic investigators with expertise in animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative imaging in the preclinical and clinical settings, and state-of-art informatics to join the CIRP network as associate members. For details, see the CIRP Associate Membership Solicitation flyer, CIRP WGs Mission Statements, and NCI CIRP Associate Membership FAQs. The associate members can contribute to developing a consensus on important co-clinical imaging issues, expand the scientific scope of the CIRP, and accelerate the dissemination of the CIRP resources.
The first special issue of the CIRP program, "Advances in Co-clinical Quantitative Imaging Research," has 13 papers published in Tomography in May of 2023.
This will be a hybrid meeting, open to the public without a registration fee.