Overview
About CIRP
The NCI initiated the Co-Clinical Imaging Research Resource Program (CIRP) in 2015 to establish web-accessible, co-clinical, quantitative imaging research resources funded under several program announcements, i.e., PAR-18-841. The CIRP supports ten different co-clinical trial projects spanning diverse tumor types, therapeutic interventions, and imaging modalities. Each CIRP resource contains four essential components, including animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative preclinical and clinical imaging methods, and informatics for supporting web resources. The deliverable of a CIRP-funded project is a web resource populated with all the methodologies, protocols, tools, and data associated with the quantitative imaging in preclinical and clinical trial settings by the end of year 5.
The CIRP network is compromised steering committee, CIRP teams, working groups, and associate members. The mission of CIRP network is to advance the practice of precision medicine by establishing consensus-based best practices for co-clinical imaging and developing optimized state-of-the-art quantitative imaging methodologies for disease detection, risk stratification, and therapeutic response assessment.
Teams and Projects
The NCI CIRP program awarded ten 5-year projects between 2017-2022. These projects focus on seven adult cancers and one pediatric cancer, including breast, bone, colon, hematology, lung, muscle, pancreas, and prostate cancers.
Working Groups
The CIRP network has three working groups (WGs), including Animal Models and Co-Clinical trials (AMCT) WG, Imaging Acquisition and Data Process (IADP) WG and InforMatics andOutReach (IMOR) WG.
Web Accessible Resources
All CIRP projects have launched a website for their web resources. A list of data collection items and the hyperlink to access these web resources are available.
Associate Members
Academic investigators with expertise in animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative imaging in the preclinical and clinical settings, and state-of-art informatics join the CIRP WGs.
Activities
CIRP holds annual meetings and organizes sessions at scientific meetings and joint sessions in other NCI conferences. CIRP annual meeting opens to public and no registration fee for attending the meeting.
News and Coming Events
Solicit Associate Members:
The CIRP network invites NCI and/or NIH supported academic investigators with expertise in animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative imaging in the preclinical and clinical settings, and state-of-art informatics to join the CIRP network as associate members, for details see the CIRP Associate Membership Solicitation flyer, CIRP WGs Mission Statements, and FAQs on NCI CIRP Associate Membership. The associate members can contribute to the development of consensus on important co-clinical imaging issues, expand the scientific scope of the CIRP, and accelerate the dissemination of the CIRP resources.
Special Issue:
The first special issue of CIRP program, "Advances in Co-clinical Quantitative Imaging Research", will be published on the Tomography.
2023 CIRP Annual Virtual Meeting, May 3-4, Rockville, MD
CIRP Annual Meeting opens to the public and no registration fee.
Selected Publications
