The goal of the CIMACs-CIDC Network is to enable systematic incorporation of biomarker studies in NCI-supported early clinical trials for immunotherapy.  CIMACs will be responsible for comprehensive analyses of biospecimens from patients for biomarkers relevant to genomic, phenotypic, and functional aspects of responses to immunotherapy. CIDC will serve the bioinformatics needs of the Network, including collection, integration, access, and analysis of data generated from CIMACs.  The CIDC will also contribute to the long-term goal of creating publically accessible Data Commons for cancer immune profiling as well as clinical data that will allow integrated analysis across trials and access by the larger immuno-oncology research community.