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  • Created 22 May 2015

About the Group

Public Description

The Center for Advanced Preclinical Research (CAPR) was founded by CCR under the direction of Terry Van Dyke in 2008. Research is based in team and collaborative science to develop and utilize reproducible preclinical studies in the development of effective therapeutics and diagnostics for human cancers. https://ccr.cancer.gov/capr-home

CAPR's mission: to facilitate development of guiding preclinical workflows for clinical research and effective cancer management

Operating Structure

  • Novel hybrid culture: integrated research rigor and project/goal management
  • Dedicated staff drawn from public and private sectors
  • Integrated expertise in cancer mechanisms, pathways, murine models, genetics, drug development, stem cell biology

Objectives

  • Engineer/adapt relevant mouse cancer models for optimal use in preclinical studies
  • Evaluate therapeutic efficacy for primary and recurrent cancers in preclinical cancer models
  • Develop novel efficacious combination therapies
  • Improve the frequency of efficacious immune system targeted therapies
  • Discover biomarkers via dynamic systems assessment
  • Generate hypothesis for clinical and basic research
  • Develop imaging technologies to monitor disease and treatment
  • Improve throughput and scale-up of preclinical studies in effective mouse models
  • Develop interactive preclinical data management systems
  • Assess relative predictive power among preclinical model types
Created by Yurong Song Last Modified n/a by Yurong Song